Introduce the reader to the phenomenon that will be the focus of the paper. Use epidemiological data to provide an overview of the issue (e.g. incidence/prevalence of the problem) and the context in which it occurs.Provide a compelling description of the clinical importance of the topic to individuals, populations, health systems and society. Consider the clinical, functional, social, financial, system and policy implications. Support all statements and claims made using current citations from core, peer-reviewed academic journals (e.g. published in past 5-10 years and/or is a “classic” reference that is seminal in the field).