Advanced Pathophysiology An understanding of cells and cell behavior is a critically important component of disease diagnosis and treatment. But some diseases can be complex in nature, with a variety of factors and circumstances impacting their emergence and severity. Effective disease analysis often requires an understanding that goes beyond isolated cell behavior. Genes, the environments in which cell processes operate, the impact of patient characteristics, and racial and ethnic variables all can have an important impact. An understanding of the signals and symptoms of alterations in cellular processes is a critical step in the diagnosis and treatment of many diseases. For APRNs, this understanding can also help educate patients and guide them through their treatment plans. In this Assignment, you examine a case study and analyze the symptoms presented. You identify cell, gene, and/or process elements that may be factors in the diagnosis, and you explain the implications to patient health. * Case Study: A 65-year-old obese African American male patient presents to his HCP with crampy left lower quadrant pain, constipation, and fevers to 101˚ F. He has had multiple episodes like this one over the past 15 years and they always responded to bowel rest and oral antibiotics. He has refused to have the recommended colonoscopy even with his history of chronic inflammatory bowel disease (diverticulitis), sedentary lifestyle, and diet lacking in fiber. His paternal grandfather died of colon cancer back in the 1950s as well. He finally underwent colonoscopy after his acute diverticulitis resolved. Colonoscopy revealed multiple polyps that were retrieved, and the pathology was positive for adenocarcinoma of the colon. Develop a 1-2 page case study analysis: Explain why you think the patient presented with the symptoms described. Identify the genes that may be associated with the development od the disease. Explain the process of immunosuppression and the effect it has on the body systems. ***Attached is the template for college of nursing papers*** References: McCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier. Chapter 1: Cellular Biology; Summary Review Chapter 2: Altered Cellular and Tissue Biology: Environmental Agents(pp. 46-61; begin again with Manifestations of Cellular Injury pp. 83-97); Summary Review Chapter 3: The Cellular Environment: Fluids and Electrolytes, Acids, and Bases, Chapter 4: Genes and Genetic Diseases (stop at Elements of formal genetics); Summary Review Chapter 5: Genes, Environment-Lifestyle, and Common Diseases (stop at Genetics of common diseases); Summary Review Chapter 7: Innate Immunity: Inflammation and Wound Healing Chapter 8: Adaptive Immunity (stop at Generation of clonal diversity); Summary Review Chapter 9: Alterations in Immunity and Inflammation (stop at Deficiencies in immunity); Summary Review Chapter 10: Infection (stop at Infectious parasites and protozoans); (start at HIV); Summary Review Chapter 11: Stress and Disease (stop at Stress, illness & coping); Summary Review Chapter 12: Cancer Biology (stop at Resistance to destruction); Summary Review Chapter 13: Cancer Epidemiology (stop at Environmental-Lifestyle factors); Summary Review https://class.content.laureate.net/f6bf9251ee3c3f606fefa59546a98a32.pdf https://www.youtube.com/watch?v=FXSuEIMrPQk https://www.youtube.com/watch?v=Jz0wx1-jTds https://www.youtube.com/watch?v=4wMEMhvrQxE https://www.youtube.com/watch?v=GmEeKVTpOKI https://www.youtube.com/watch?v=bLajK5Vy55M ****All sources must be scholarly sources not to exceed 5 years old. Grading Rubic for assignment: javascript:ActivateLink(‘M01.CSAS1.RUBRIC’,true)