Write a paper explaining why COVID-19-related deaths have several principal points to be considered. First, despite the negative PCR test at screening and absence of increased temperature at the time of first vaccine dose administration, the onset of the first COVID-19 symptom (4 5 days after first dose, similar to the average COVID-19 incubation period) testifies that participants had been infected with SARS-CoV-2 before or near the vaccination day, which was additionally confirmed by the IDMC, on the basis of WHO and CDC guidelines and review of underlying clinical data. Second, both participants self-administered non-steroidal anti-inflammatory drugs without informing clinicians, which interfered with diagnosis and receipt of medical help upon hospital admission.